| VB4-845: VICINIUM™
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| Protein Expression & Purification |
Development of a GMP Phase III purification process for VB4-845, an immunotoxin expressed in E.coli using high cell density fermentation
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2011 |
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Drug Design Development & Therapy
A Phase I Study of an Intravesical Administered Immunotoxin Targeting EpCAM for the treatment of Non Muscle-Invasive Bladder Cancer in BCG Refractory and BCG Intolerant Patients |
2010 |
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Cancer Biotherapy & Radiopharmaceuticals
Preclinical Assessment of an Anti-EpCAM Immunotoxin: Locoregional Delivery Provides a Safer Alternative to Systemic Administration |
2009 |
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Preclinical Safety Evaluation of BioPharmaceuticals Chapter 29
Preclinical Safety Evaluation of Immunotoxins |
2008 |
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Current Opinion of Molecular Therapy
VB4-845, a conjugated recombinant antibody and immunotoxin for head & neck and bladder cancer |
2008 |
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Level of Expression of EpCAM and Response to Vicinium™ in Non Muscle-Invasive Transitional Cell Carcinoma of the Bladder
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2010 |
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Frequency and Level of Expression of EpCAM in Non Muscle-Invasive Transitional Cell Carcinoma of the Bladder |
2009 |
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Treatment with Intravesical Vicinium™ Results in Durable Responses in Patients with Carcinoma in situ (CIS) Previously Treated With Bacille Calmette-Guérin (BCG) |
2009 |
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A Phase I/II Study of Vicinium™ Given by Intravesical Administration in Patients with Superficial Transitional Cell Carcinoma of the Bladder: Phase I Final Results |
2007 |
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| VB4-845: PROXINIUM™
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Cancer Biotherapy & Radiopharmaceuticals Preclinical
Assessment of an Anti-EpCAM Immunotoxin: Locoregional Delivery Provides a Safer Alternative to Systemic Administration
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2009 |
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Preclinical Safety Evaluation of BioPharmaceuticals Chapter 29
Preclinical Safety Evaluation of Immunotoxins |
2008 |
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Current Opinion of Molecular Therapy
VB4-845, a conjugated recombinant antibody and immunotoxin for head and neck cancer and bladder cancer |
2008 |
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Journal of Drug Design, Development and Therapy
A phase I clinical study of VB4-845: Weekly intratumoral administration of an anti-EpCAM recombinant fusion protein in patients with squamous cell carcinoma of the head and neck |
2008 |
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Medical Oncology
A phase I clinical study of intratumorally administered VB4-845, an anti-epithelial cell adhesion molecule recombinant fusion protein, in patients with squamous cell carcinoma of the head and neck |
2008 |
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Clinical Cancer Research
A Recombinant Immunotoxin Derived from a Humanized Epithelial Cell Adhesion Molecule-specific Single-Chain Antibody Fragment Has Potent and Selective Antitumor Activity |
2003 |
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Treatment of Squamous Cell Carcinoma of the Head and Neck with Proxinium™: Preliminary Results
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2008 |
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Evaluation of the immunotoxin, Proxinium™ in combination with chemotherapy and radiotherapy
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2007 |
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A Phase I Study of VB4-845 in Patients with Advanced, Recurrent Head and Neck Cancer on a Weekly Dosing Scheme
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2005 |
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| VB6-845
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Journal of Immunotherapy
Engineering and Biological Characterization of VB6-845, an Anti-EpCAM Immunotoxin Containing a T-cell Epitope-depleted Variant of the Plant Toxin Bouganin
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2009 |
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A Phase I Study of VB6-845, an Anti-EpCAM Fusion Protein Targeting Advanced Solid Tumours of Epithelial Origin: Preliminary Results |
2008 |
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Intracellular trafficking of VB6-845, an immunocytotoxin containing a de-immunized variant of bouganin |
2008 |
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Enhancement of expression of a Fab format of a cytotoxic therapeutic protein produced in an Escherichia coli expression system; scale up of process from 15 L development scale to 1200 L production scale for phase I trials |
2007 |
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Complete regression of ovarian cancer xenografts following treatment with the recombinant immunocytotoxic protein, VB6-845 |
2006 |
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A preclinical profile of VB6-845: a recombinant immunotoxin for targeting ovarian cancer |
2006 |
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Recombinant Engineering of an EpCAM-specific Fab antibody (VB6-845) with de-immunized bouganin |
2005 |
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Functional and biological characterization of VB6-845, a recombinant EpCAM-specific Fab antibody genetically-linked with de-immunized Bouganin (De-Bouganin) |
2005 |
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